|
KMID : 0606920190270050457
|
|
Biomolecules & Therapeutics
2019 Volume.27 No. 5 p.457 ~ p.465
|
|
|
Enrichment of Short-Chain Ceramides and Free Fatty Acids in the Skin Epidermis, Liver, and Kidneys of db/db Mice, a Type 2 Diabetes Mellitus Model
|
|
Kim Min-Jeong
Jeong Haeng-Dueng
Lee Bu-Hyun
Cho Ye-Jin
Yoon Won-Kee
Cho Ah-Reum
Kwon Gui-Deock
Nam Ki-Taek
Ha Hun-Joo
Lim Kyung-Min
|
|
|
Abstract
|
|
|
|
Patients with diabetes mellitus (DM) often suffer from diverse skin disorders, which might be attributable to skin barrier dysfunction. To explore the role of lipid alterations in the epidermis in DM skin disorders, we quantitated 49 lipids (34 ceramides, 14 free fatty acids (FFAs), and cholesterol) in the skin epidermis, liver, and kidneys of db/db mice, a Type 2 DM model, using UPLC-MS/ MS. The expression of genes involved in lipid synthesis was also evaluated. With the full establishment of hyperglycemia at the age of 20 weeks, remarkable lipid enrichment was noted in the skin of the db/db mice, especially at the epidermis and subcutaneous fat bed. Prominent increases in the ceramides and FFAs (>3 fold) with short or medium chains (
|
|
|
KEYWORD
|
|
|
Lipids, Ceramide, Free fatty acid, Diabetes mellitus, Skin barrier function
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|